Josie and the Pussycats are in San Francisco for a concert and are in trouble with a Scary Ghoul. The band turns to Mystery, Inc. for help. As luck would have it, they are already in San Francisco on a fishing trip in Fisherman's Wharf. But why is the Scary Ghoul haunting the Pussycats? Could Alexandra Cabot have gone too far this time? Alexandra's fight with Daphne seems to suggest it.
In one scene, Daphne gets into an argument with Alexandra which parodies the real-life argument that took place shortly before British European Airways Flight 548 crashed due to pilot error, killing everyone onboard.