In Tel Aviv, Mystery, Inc. is investigating attacks on the US Embassy in Israel by the Demon Lilith. While they are in Israel, Shaggy and Scooby-Doo take an interest in the food. With them are a young Jewish-American teenager named Samson and his dog Goliath who are visiting Israel for a couple of days. When he hits two wrist bands, Samson becomes a superhero version of the biblical character that gave him his name and Goliath turns into a lion. But will they be enough to stop the Demon Lilith?